Myocardial ischemia reperfusion injury and cardioprotection in the presence of sensory neuropathy therapeutic options /
During the last decades, mortality of acute myocardial infarction has been dramatically improved, however, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischemic conditioning have been discovered more than 3 decades ago, however, its clinical translation is...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | BRITISH JOURNAL OF PHARMACOLOGY
177 No. 23 |
| doi: | 10.1111/bph.15021 |
| mtmt: | 31179089 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18876 |
| Tartalmi kivonat: | During the last decades, mortality of acute myocardial infarction has been dramatically improved, however, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischemic conditioning have been discovered more than 3 decades ago, however, its clinical translation is still an unmet need, mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors and comorbidities and their medications. Sensory neuropathy is one of the comorbidities that has been shown to interfere with cardioprotection. In the present review we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which neuropathies may interfere with ischemic heart disease and cardioprotective signalling. Moreover, we suggest future therapeutic options targeting ischemic heart and sensory neuropathy simultaneously. |
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| Terjedelem/Fizikai jellemzők: | 5336-5356 |
| ISSN: | 0007-1188 |