Myocardial ischemia reperfusion injury and cardioprotection in the presence of sensory neuropathy therapeutic options /

During the last decades, mortality of acute myocardial infarction has been dramatically improved, however, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischemic conditioning have been discovered more than 3 decades ago, however, its clinical translation is...

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Bibliographic Details
Main Authors: Bencsik Péter
Gömöri Kamilla
Szabados Tamara
Sántha Péter
Helyes Zsuzsanna
Jancsó Gábor
Ferdinandy Péter
Görbe Anikó
Format: Article
Published: 2020
Series:BRITISH JOURNAL OF PHARMACOLOGY 177 No. 23
doi:10.1111/bph.15021

mtmt:31179089
Online Access:http://publicatio.bibl.u-szeged.hu/18876
Description
Summary:During the last decades, mortality of acute myocardial infarction has been dramatically improved, however, the incidence of post-infarction heart failure is still increasing. Cardioprotection by ischemic conditioning have been discovered more than 3 decades ago, however, its clinical translation is still an unmet need, mainly due to the disrupted cardioprotective signalling pathways in the presence of different cardiovascular risk factors and comorbidities and their medications. Sensory neuropathy is one of the comorbidities that has been shown to interfere with cardioprotection. In the present review we summarize the diverse aetiology of sensory neuropathies and the mechanisms by which neuropathies may interfere with ischemic heart disease and cardioprotective signalling. Moreover, we suggest future therapeutic options targeting ischemic heart and sensory neuropathy simultaneously.
Physical Description:5336-5356
ISSN:0007-1188