Kupffer cell phagocytosis blockade decreases morbidity in endotoxemic rats with obstructive jaundice
Objective and design: The consequences of Kupffer cell phagocytosis blockade were studied in endotoxemic rats with obstructive jaundice. Material or Subjects: 159 male Wistar rats. Treatment: Obstructive jaundice was induced by bile duct ligation (BDL). Gadolinium chloride (1 mg/100g iv) was given 6...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2002
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| Sorozat: | INFLAMMATION RESEARCH
51 No. 10 |
| doi: | 10.1007/PL00012421 |
| mtmt: | 1320830 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18765 |
| LEADER | 02309nab a2200301 i 4500 | ||
|---|---|---|---|
| 001 | publ18765 | ||
| 005 | 20200528151206.0 | ||
| 008 | 200528s2002 hu o 0|| zxx d | ||
| 022 | |a 1023-3830 | ||
| 024 | 7 | |a 10.1007/PL00012421 |2 doi | |
| 024 | 7 | |a 1320830 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Lázár György ifj. | |
| 245 | 1 | 0 | |a Kupffer cell phagocytosis blockade decreases morbidity in endotoxemic rats with obstructive jaundice |h [elektronikus dokumentum] / |c Lázár György ifj. |
| 260 | |c 2002 | ||
| 300 | |a 511-518 | ||
| 490 | 0 | |a INFLAMMATION RESEARCH |v 51 No. 10 | |
| 520 | 3 | |a Objective and design: The consequences of Kupffer cell phagocytosis blockade were studied in endotoxemic rats with obstructive jaundice. Material or Subjects: 159 male Wistar rats. Treatment: Obstructive jaundice was induced by bile duct ligation (BDL). Gadolinium chloride (1 mg/100g iv) was given 6 days after BDL to inhibit Kupffer cell activity and the animals were challenged with 1 mug/g endotoxin 24 h later. Methods: Endotoxin sensitivity, tumor necrosis factor-a and interleukin-6 production were studied, liver and lung injury were assessed by neutrophil infiltration assay, tissue adenosine triphosphate, aspartate aminotransferase, alanine aminotransferase level determinations and histology, respectively. For statistics non-parametric methods were used. Results: BDL sensitized the animals to endotoxin, increased endotoxin-induced tumor necrosis factor-a and interleukin-6 production and reduced ATP contents of the liver and the lung. Kupffer cell blockade significantly increased the resistance against endotoxin, diminished the inflammatory cytokine release and reduced endotoxin-induced tissue injury in BDL animals. Conclusion: Attenuation of Kupffer cell function decreases endotoxin-induced lethality and morbidity in obstructive jaundice. | |
| 700 | 0 | 1 | |a Paszt Attila |e aut |
| 700 | 0 | 1 | |a Kaszaki József |e aut |
| 700 | 0 | 1 | |a Duda Ernő |e aut |
| 700 | 0 | 1 | |a Szakács Júlia |e aut |
| 700 | 0 | 1 | |a Tiszlavicz László |e aut |
| 700 | 0 | 1 | |a Boros Mihály |e aut |
| 700 | 0 | 1 | |a Balogh Ádám |e aut |
| 700 | 0 | 1 | |a Lázár György |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/18765/1/lazar_kupffer-cell-phagocytosis_inflamm_res_51_2002_511-518..pdf |z Dokumentum-elérés |