Integrated evolutionary analysis reveals antimicrobial peptides with limited resistance

Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study the evolution of resistance to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli. Our work indicates that evolution of resistanc...

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Bibliographic Details
Main Authors: Spohn Réka
Daruka Lejla
Lázár Viktória
Martins Ana
Vidovics Fanni
Grézal Gábor
Méhi Orsolya Katinka
Kintses Bálint
Számel Mónika
Jangir Pramod Kumar
Csörgő Bálint
Györkei Ádám
Bódi Zoltán
Faragó Anikó
Bodai László
Földesi Imre
Kata Diána
Maróti Gergely
Pap Bernadett
Wirth Roland
Papp Balázs
Pál Csaba
Format: Article
Published: 2019
Series:NATURE COMMUNICATIONS 10
doi:10.1038/s41467-019-12364-6

mtmt:30865039
Online Access:http://publicatio.bibl.u-szeged.hu/18612
Description
Summary:Antimicrobial peptides (AMPs) are promising antimicrobials, however, the potential of bacterial resistance is a major concern. Here we systematically study the evolution of resistance to 14 chemically diverse AMPs and 12 antibiotics in Escherichia coli. Our work indicates that evolution of resistance against certain AMPs, such as tachyplesin II and cecropin P1, is limited. Resistance level provided by point mutations and gene amplification is very low and antibiotic-resistant bacteria display no cross-resistance to these AMPs. Moreover, genomic fragments derived from a wide range of soil bacteria confer no detectable resistance against these AMPs when introduced into native host bacteria on plasmids. We have found that simple physicochemical features dictate bacterial propensity to evolve resistance against AMPs. Our work could serve as a promising source for the development of new AMP-based therapeutics less prone to resistance, a feature necessary to avoid any possible interference with our innate immune system.
Physical Description:Azonosító: 4538-Terjedelem: 13 p
ISSN:2041-1723