Synthesis of Fluorine-Containing Molecular Entities Through Fluoride Ring Opening of Oxiranes and Aziridines

The current minireview highlights the most relevant methodologies for the creation of fluorinated scaffolds accessed through transformations of three-membered heterocycles (oxiranes and aziridines) involving their opening with various nucleophilic fluorinating agents reported over recent years. The...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Remete Attila Márió
Kiss Loránd
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2019 No. 33
doi:10.1002/ejoc.201900981

mtmt:30929734
Online Access:http://publicatio.bibl.u-szeged.hu/17870
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520 3 |a The current minireview highlights the most relevant methodologies for the creation of fluorinated scaffolds accessed through transformations of three-membered heterocycles (oxiranes and aziridines) involving their opening with various nucleophilic fluorinating agents reported over recent years. The purpose of the review is also to provide an overview of the ring-opening synthetic practices with fluoride towards different functionalized, fluorine-containing scaffolds with the focus on regioselectivity/regiocontrol and enantioselectivity including symmetric or unsymmetric monoheterocycles, cycloalkane-fused oxiranes and aziridines. 
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