Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles a Simple Access to alpha,alpha-Dideutero Amines /
A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable alpha,alpha-dideutero analogues. Raney nickel proved to be a useful catalyst for the transformation of a wide range of nitriles unde...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | CHEMPLUSCHEM
84 No. 10 |
| doi: | 10.1002/cplu.201900526 |
| mtmt: | 30901293 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/17868 |
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| 024 | 7 | |a 30901293 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Mészáros Rebeka Ildikó | |
| 245 | 1 | 0 | |a Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles |h [elektronikus dokumentum] : |b a Simple Access to alpha,alpha-Dideutero Amines / |c Mészáros Rebeka Ildikó |
| 260 | |c 2019 | ||
| 300 | |a 1508-1511 | ||
| 490 | 0 | |a CHEMPLUSCHEM |v 84 No. 10 | |
| 520 | 3 | |a A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable alpha,alpha-dideutero analogues. Raney nickel proved to be a useful catalyst for the transformation of a wide range of nitriles under reasonably mild conditions with excellent deuterium incorporation (>90 %) and quantitative conversion. Among known model compounds, three new deuterated primary amines were prepared. The large-scale synthesis of deuterated tryptamine was also carried out to deliver 1.1 g product under flow conditions. | |
| 700 | 0 | 1 | |a Peng Bai-Jing |e aut |
| 700 | 0 | 1 | |a Ötvös Sándor Balázs |e aut |
| 700 | 0 | 1 | |a Yang Shyh-Chyun |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/17868/1/M-sz-ros_et_al-2019-ChemPlusChem.pdf |z Dokumentum-elérés |