Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles a Simple Access to alpha,alpha-Dideutero Amines /
A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable alpha,alpha-dideutero analogues. Raney nickel proved to be a useful catalyst for the transformation of a wide range of nitriles unde...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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2019
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| Sorozat: | CHEMPLUSCHEM
84 No. 10 |
| doi: | 10.1002/cplu.201900526 |
| mtmt: | 30901293 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/17868 |
| Tartalmi kivonat: | A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable alpha,alpha-dideutero analogues. Raney nickel proved to be a useful catalyst for the transformation of a wide range of nitriles under reasonably mild conditions with excellent deuterium incorporation (>90 %) and quantitative conversion. Among known model compounds, three new deuterated primary amines were prepared. The large-scale synthesis of deuterated tryptamine was also carried out to deliver 1.1 g product under flow conditions. |
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| Terjedelem/Fizikai jellemzők: | 1508-1511 |
| ISSN: | 2192-6506 |