Validity of the EQ‐5D in patients with pemphigus vulgaris and pemphigus foliaceus
BACKGROUND: No studies have employed the EuroQoL (EQ-5D) questionnaire to assess health-related quality of life (HRQoL) in pemphigus patients, to date. OBJECTIVES: To evaluate HRQoL of pemphigus patients by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patien...
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| Dokumentumtípus: | Cikk |
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2019
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| Sorozat: | BRITISH JOURNAL OF DERMATOLOGY
180 No. 4 |
| doi: | 10.1111/bjd.16883 |
| mtmt: | 3386013 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/17565 |
| Tartalmi kivonat: | BACKGROUND: No studies have employed the EuroQoL (EQ-5D) questionnaire to assess health-related quality of life (HRQoL) in pemphigus patients, to date. OBJECTIVES: To evaluate HRQoL of pemphigus patients by the EQ-5D and to analyse the convergent and known-groups validity of the EQ-5D in this patient population. METHODS: Between 2014 and 2017, a multicentre cross-sectional study was carried out. Outcome measures included the five-level EQ-5D (EQ-5D-5L), Dermatology Life Quality Index (DLQI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and an average pain intensity visual analogue scale (VAS) for the past three months. RESULTS: 109 consecutive patients with pemphigus participated in the study (mean age 57 years; women 64%). Among the EQ-5D dimensions, the most problems were reported regarding pain/discomfort (50%), mobility (43%) and anxiety/depression (43%). No significant difference was found in mean EQ-5D index scores between patients with pemphigus vulgaris and foliaceus (0.81 vs. 0.86; p=0.142). Mean EQ-5D index scores of patients with limited, moderate, significant and extreme pemphigus were 0.88, 0.82, 0.72 and 0.67, respectively (p=0.001). The number of comorbidities was associated with greater impairment in EQ-5D index scores (p<0.001). DLQI (rs =-0.62; p<0.001) and the average pain intensity VAS (rs =-0.59; p<0.001) more strongly correlated with the EQ-5D index scores than ABSIS (rs =-0.40; p<0.001). CONCLUSIONS: This is the first study employing the EQ-5D questionnaire in pemphigus. The EQ-5D is a valid measure of HRQoL in pemphigus patients that can be useful both in clinical practice and in economic evaluations to assess the health gains associated with new effective treatments. This article is protected by copyright. All rights reserved. |
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| Terjedelem/Fizikai jellemzők: | 802-809 |
| ISSN: | 0007-0963 |