Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic as...

Full description

Saved in:
Bibliographic Details
Main Authors: Zhao Jian
Wu Hui
Langefeld Carl D.
Kaufman Kenneth M.
Kelly Jennifer A.
Börcsökné Endreffy Emőke
Kovács László
Bae Sang-Cheol
Alarcón-Riquelme Marta E.
Alarcón Graciela S.
Anaya Juan-Manuel
Criswell Lindsey A.
Freedman Barry I.
Kamen Diane L.
Gilkeson Gary S.
Format: Article
Published: 2015
Series:CLINICAL IMMUNOLOGY 161 No. 2
doi:10.1016/j.clim.2015.09.007

mtmt:3119532
Online Access:http://publicatio.bibl.u-szeged.hu/17550
Description
Summary:Leptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE. © 2015 Elsevier Inc.
Physical Description:157-162
ISSN:1521-6616