Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis.
We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | POLISH JOURNAL OF PATHOLOGY
70 No. 2 |
| doi: | 10.5114/pjp.2019.87105 |
| mtmt: | 30842250 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/17098 |
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| 260 | |c 2019 | ||
| 300 | |a 139-143 | ||
| 490 | 0 | |a POLISH JOURNAL OF PATHOLOGY |v 70 No. 2 | |
| 520 | 3 | |a We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth. | |
| 700 | 0 | 1 | |a Serfőző Orsolya |e aut |
| 700 | 0 | 1 | |a Ambrózay Éva |e aut |
| 700 | 0 | 1 | |a Markó László |e aut |
| 700 | 0 | 1 | |a Krenács László |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/17098/1/PolJPathol-2019-70-139-143-SpontRegrTNBC.pdf |z Dokumentum-elérés |