Spontaneous pathological complete regression of high-grade triple-negative breast cancer with axillary metastasis.

We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy...

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Bibliographic Details
Main Authors: Cserni Gábor
Serfőző Orsolya
Ambrózay Éva
Markó László
Krenács László
Format: Article
Published: 2019
Series:POLISH JOURNAL OF PATHOLOGY 70 No. 2
doi:10.5114/pjp.2019.87105

mtmt:30842250
Online Access:http://publicatio.bibl.u-szeged.hu/17098
Description
Summary:We report on a breast carcinoma with medullary features diagnosed by core needle biopsy in a 72-year-old woman. Both the primary tumour and its fine needle aspiration-proven, rapidly growing axillary metastasis regressed completely in less than 2 months, by the time surgery was performed. The biopsy of the primary tumour demonstrated a dense stromal infiltrate of CD8+/granzyme B+ activated cytotoxic T-cells suggestive of a robust antitumour immune response. Paradoxically, both tumour cells and tumour infiltrating immune cells demonstrated a diffuse PD-L1 expression, revealing that antitumour immune response has the ability to spontaneously overcome inhibitory mechanisms induced by cancerous growth.
Physical Description:139-143
ISSN:1233-9687