Changes in Redox Signaling in the Skeletal Muscle with Aging

Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality). Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs. Mitochondrial dysfuncti...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Szentesi Péter
Csernoch László
Dux László
Keller-Pintér Anikó
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2019
doi:10.1155/2019/4617801

mtmt:30410578
Online Access:http://publicatio.bibl.u-szeged.hu/16802
Leíró adatok
Tartalmi kivonat:Reduction in muscle strength with aging is due to both loss of muscle mass (quantity) and intrinsic force production (quality). Along with decreased functional capacity of the muscle, age-related muscle loss is associated with corresponding comorbidities and healthcare costs. Mitochondrial dysfunction and increased oxidative stress are the central driving forces for age-related skeletal muscle abnormalities. The increased oxidative stress in the aged muscle can lead to altered excitation-contraction coupling and calcium homeostasis. Furthermore, apoptosis-mediated fiber loss, atrophy of the remaining fibers, dysfunction of the satellite cells (muscle stem cells), and concomitant impaired muscle regeneration are also the consequences of increased oxidative stress, leading to a decrease in muscle mass, strength, and function of the aged muscle. Here we summarize the possible effects of oxidative stress in the aged muscle and the benefits of physical activity and antioxidant therapy.
Terjedelem/Fizikai jellemzők:Terjedelem: 12 p-Azonosító: 4617801
ISSN:1942-0900