The effect of serum triglyceride concentration on the outcome of acute pancreatitis

Elevated serum triglyceride concentration (seTG, >1.7 mM or >150 mg/dL) or in other words hypertriglyceridemia (HTG) is common in the populations of developed countries. This condition is accompanied by an increased risk for various diseases, such as acute pancreatitis (AP). It has been propos...

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Bibliographic Details
Main Authors: Kiss Lóránd
Fűr Gabriella
Mátrai Péter
Hegyi Péter
Ivány Emese
Szabó Imre
Habon Tamás
Alizadeh Hussain
Gyöngyi Zoltán
Vigh Éva
Erőss Bálint Mihály
Erős Adrienn
Czakó László
Rakonczay Zoltán, ifj
Format: Article
Published: 2018
Series:SCIENTIFIC REPORTS 8 No. 1
doi:10.1038/s41598-018-32337-x

mtmt:3422217
Online Access:http://publicatio.bibl.u-szeged.hu/15411
Description
Summary:Elevated serum triglyceride concentration (seTG, >1.7 mM or >150 mg/dL) or in other words hypertriglyceridemia (HTG) is common in the populations of developed countries. This condition is accompanied by an increased risk for various diseases, such as acute pancreatitis (AP). It has been proposed that HTG could also worsen the course of AP. Therefore, in this meta-analysis, we aimed to compare the effects of various seTGs on the severity, mortality, local and systemic complications of AP, and on intensive care unit admission. 16 eligible studies, including 11,965 patients were retrieved from PubMed and Embase. The results showed that HTG significantly elevated the odds ratio (OR = 1.72) for severe AP when compared to patients with normal seTG (<1.7 mM). Furthermore, a significantly higher occurrence of pancreatic necrosis, persistent organ failure and renal failure was observed in groups with HTG. The rates of complications and mortality for AP were significantly increased in patients with seTG >5.6 mM or >11.3 mM versus <5.6 mM or <11.3 mM, respectively. We conclude that the presence of HTG worsens the course and outcome of AP, but we found no significant difference in AP severity based on the extent of HTG.
Physical Description:Azonosító: 14096-Terjedelem: 14 p
ISSN:2045-2322