Traceless chirality transfer from a norbornene beta-amino acid to pyrimido[2,1-a]isoindole enantiomers
The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(-)-(1R,2S,3MS)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(-)-1] was successfully transfered to heterocycles...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2017
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| Sorozat: | TETRAHEDRON-ASYMMETRY
28 No. 10 |
| doi: | 10.1016/j.tetasy.2017.07.006 |
| mtmt: | 3317911 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/14936 |
| Tartalmi kivonat: | The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(-)-(1R,2S,3MS)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(-)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (-)-9b, (-)-10b and (-)-10c. (C) 2017 Elsevier Ltd. All rights reserved. |
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| Terjedelem/Fizikai jellemzők: | 1401-1406 |
| ISSN: | 0957-4166 |