The Role of Lipids and Membranes in the Pathogenesis of Alzheimer's Disease

Lipids participate in amyloid precursor protein (APP) trafficking and processing ‒ important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Penke Botond
Paragi Gábor
Gera János
Berkecz Róbert
Kovács Zsolt
Crul Tim
Vigh László
Dokumentumtípus: Cikk
Megjelent: 2018
Sorozat:CURRENT ALZHEIMER RESEARCH 15 No. 13
doi:10.2174/1567205015666180911151716

mtmt:30309769
Online Access:http://publicatio.bibl.u-szeged.hu/14406
Leíró adatok
Tartalmi kivonat:Lipids participate in amyloid precursor protein (APP) trafficking and processing ‒ important factors in the initiation of Alzheimer's disease (AD) pathogenesis and influence the formation of neurotoxic β-amyloid (Aβ) peptides. An important risk factor, the presence of ApoE4 protein in AD brain cells binds the lipids to AD. In addition, lipid signaling pathways have a crucial role in the cellular homeostasis, and depend on specific protein-lipid interactions. The current review focuses on pathological alterations of membrane lipids (cholesterol, glycerophospholipids, sphingolipids) and lipid metabolism in AD and provides insight in the current understanding of biological membranes, their lipid structures and functions, as well as their role as potential therapeutic targets. Novel methods for studying the membrane structure and lipid composition will be reviewed in a broad sense whereas the use of lipid biomarkers for early diagnosis of AD will be shortly summarized. Interactions of Aβ peptides with the cell membrane and different subcellular organelles are reviewed. Next, the details of the most important lipid signaling pathways, including the role of plasma membrane as stress sensor and its therapeutic applications are given. 4-hydroxy-2-nonenal may play a special role in the initiation of the pathogenesis of AD and thus the "calpain-cathepsin hypothesis" of AD is also highlighted. Finally, the most important lipid dietary factors and their possible use and efficacy in the prevention of AD are discussed.
Terjedelem/Fizikai jellemzők:1191-1212
ISSN:1567-2050