Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey
Here we examine the carbapenem and metronidazole resistance mechanisms of 640 Bacteroides strains reported in the 2008-2009 European antibiotic susceptibility survey. Of the 22 strains with elevated imipenem minimum inhibitory concentrations (≥4 μg/mL), 10 were cfiA-positive and out of these 5 carri...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2013
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| Sorozat: | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
41 No. 2 |
| doi: | 10.1016/j.ijantimicag.2012.10.001 |
| mtmt: | 2196925 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/13013 |
| Tartalmi kivonat: | Here we examine the carbapenem and metronidazole resistance mechanisms of 640 Bacteroides strains reported in the 2008-2009 European antibiotic susceptibility survey. Of the 22 strains with elevated imipenem minimum inhibitory concentrations (≥4 μg/mL), 10 were cfiA-positive and out of these 5 carried activating insertion sequence (IS) elements in the upstream regions of the cfiA genes. However, resistant strains with cfiA genes but with no activating IS elements were found (n = 2) as well as a resistant strain with no cfiA gene. In the former the resistance phenotypes by Etest were heterogeneous, whilst in the latter no carbapenemase production was seen; both mechanisms have been rarely observed, examined and characterised. Interestingly, few (n = 3) nim-positive strains were found, including one metronidazole- resistant strain harbouring nimE activated by ISBf6, and two susceptible strains harbouring chromosomally located nim genes. © 2012 Elsevier B.V. and the International Society of Chemotherapy. |
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| Terjedelem/Fizikai jellemzők: | 122-125 |
| ISSN: | 0924-8579 |