Activation of TRPV3 regulates inflammatory actions of human epidermal keratinocytes

Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on non-neuronal cell types. Emerging findings have highlighted...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Szöllősi Attila Gábor
Vasas Nikolett
Angyal Ágnes
Kistamás Kornél
Nánási Péter Pál
Mihály Johanna
Béke Gabriella
Herczeg-Lisztes Erika
Szegedi Andrea
Kawada Naoki
Yanagida Takashi
Mori Takahiro
Kemény Lajos
Bíró Tamás
Dokumentumtípus: Cikk
Megjelent: 2018
Sorozat:JOURNAL OF INVESTIGATIVE DERMATOLOGY 138 No. 2
doi:10.1016/j.jid.2017.07.852

mtmt:3319610
Online Access:http://publicatio.bibl.u-szeged.hu/12990
Leíró adatok
Tartalmi kivonat:Transient receptor potential (TRP) ion channels were first characterized on neurons, where they are classically implicated in sensory functions; however, research in recent decades has shown that many of these channels are also expressed on non-neuronal cell types. Emerging findings have highlighted the role of TRP channels in the skin, where they have been shown to be important in numerous cutaneous functions. Of particular interest is TRPV3, which was first described on keratinocytes. Its functional importance was supported when its gain-of-function mutation was linked to Olmsted syndrome, which is characterized by palmoplantar keratoderma, periorifacial hyperkeratosis, diffuse hypotrichosis and alopecia, as well as itch. In spite of these exciting results, we have no information about the role and functionality of TRPV3 on keratinocytes at the cellular level. In our current study, we have identified TRPV3 expression both on human skin and cultured epidermal keratinocytes. TRPV3 stimulation was found to function as a Ca2+-permeable ion channel which suppresses proliferation of epidermal keratinocytes and induces cell death. Stimulation of the channel also triggers a strong proinflammatory response via the NF-?B pathway. Collectively our data shows that TRPV3 is functionally expressed on human epidermal keratinocytes and that it plays a role in cutaneous inflammatory processes.
Terjedelem/Fizikai jellemzők:365-374
ISSN:0022-202X