Functionalized Dialdehydes as Promising Scaffolds for Access to Heterocycles and beta-Amino Acids Synthesis of Fluorinated Piperidine and Azepane Derivatives /

Functionalized Dialdehydes as Promising Scaffolds for Access to Heterocycles and beta-Amino Acids Synthesis of Fluorinated Piperidine and Azepane Derivatives /

Functionalized dialdehydes are considered important substrates that can be transformed into various substituted heterocyclic, alicyclic, and polysubstituted compounds. Here, we report a robust stereocontrolled procedure for the synthesis of novel functionalized trifluoromethyl-containing piperidine...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Ábrahámi Renáta
Kiss Loránd
Fustero Santos
Fülöp Ferenc
Dokumentumtípus: Cikk
Megjelent: Thieme 2017
Sorozat:SYNTHESIS-STUTTGART 49 No. 6
doi:10.1055/s-0036-1588396

mtmt:3226662
Online Access:http://publicatio.bibl.u-szeged.hu/12553
Leíró adatok
Tartalmi kivonat:Functionalized dialdehydes are considered important substrates that can be transformed into various substituted heterocyclic, alicyclic, and polysubstituted compounds. Here, we report a robust stereocontrolled procedure for the synthesis of novel functionalized trifluoromethyl-containing piperidine and azepane derivatives, based on oxidative ring cleavage of the C=C bond of diversely substituted cycloalkenes, followed by reductive ring closure of the diformyl intermediates in the presence of fluorine-containing amines.
Terjedelem/Fizikai jellemzők:1206-1213
ISSN:0039-7881

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