Functionalized Dialdehydes as Promising Scaffolds for Access to Heterocycles and beta-Amino Acids Synthesis of Fluorinated Piperidine and Azepane Derivatives /
Functionalized dialdehydes are considered important substrates that can be transformed into various substituted heterocyclic, alicyclic, and polysubstituted compounds. Here, we report a robust stereocontrolled procedure for the synthesis of novel functionalized trifluoromethyl-containing piperidine...
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| Main Authors: | |
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| Format: | Article |
| Published: |
Thieme
2017
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| Series: | SYNTHESIS-STUTTGART
49 No. 6 |
| doi: | 10.1055/s-0036-1588396 |
| mtmt: | 3226662 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/12553 |
| Summary: | Functionalized dialdehydes are considered important substrates that can be transformed into various substituted heterocyclic, alicyclic, and polysubstituted compounds. Here, we report a robust stereocontrolled procedure for the synthesis of novel functionalized trifluoromethyl-containing piperidine and azepane derivatives, based on oxidative ring cleavage of the C=C bond of diversely substituted cycloalkenes, followed by reductive ring closure of the diformyl intermediates in the presence of fluorine-containing amines. |
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| Physical Description: | 1206-1213 |
| ISSN: | 0039-7881 |