The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer

The presence of multifocality and the aggregate tumor size were retrospectively analysed in adatabase of 1071 operated breast cancers. Around aquarter of all these cancers involved multiple foci, while atenth of the total demonstrated more than one invasive focus. Although the multifocal cancers wer...

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Bibliographic Details
Main Authors: Kelemen Gyöngyi
Farkas V.
Debrah J.
Ormándi Katalin
Vörös András
Kaizer László
Varga Zoltán
Lázár György, ifj
Kahán Zsuzsanna
Format: Article
Published: 2012
Series:NEOPLASMA 59 No. 5
doi:10.4149/neo_2012_073

mtmt:2046085
Online Access:http://publicatio.bibl.u-szeged.hu/12547
Description
Summary:The presence of multifocality and the aggregate tumor size were retrospectively analysed in adatabase of 1071 operated breast cancers. Around aquarter of all these cancers involved multiple foci, while atenth of the total demonstrated more than one invasive focus. Although the multifocal cancers were smaller and more often screen-detected than the unifocal cancers, their aggregate tumor size was larger, and they more frequently displayed casting-type calcifications in the mammogram and HER2 positivity. Lobular histology favoured larger tumor burden. The invasive multifocal cancers were more commonly lymph node-positive than the other tumors. In asubgroup of 584 patients with amedian follow-up time of 5 years, the larger size of the invasive tumor, the presence of LVI or lymph node involvement, HER2 positivity and triple negativity were associated with apoorer RFS and OS, while the outcome of screen-detected tumors was superior to that of non-screen-detected or interval cancers. Alarge tumor size, lymph node positivity and HER2 positive or triple negative phenotypes were independent determinants of apoorer survival rate. Keywords: breast cancer, multifocality, prognostic factor, tumor burden.
Physical Description:566-573
ISSN:0028-2685