High-coverage whole-exome sequencing identifies candidate genes for suicide in victims with major depressive disorder

We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequen...

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Bibliographic Details
Main Authors: Tombácz Dóra
Maróti Zoltán
Kalmár Tibor
Csabai Zsolt
Balázs Zsolt
Takahashi Shinichi
Palkovits Miklós
Snyder Michael
Boldogkői Zsolt
Format: Article
Published: Nature Publishing Group 2017
Series:SCIENTIFIC REPORTS 7 No. 1
doi:10.1038/s41598-017-06522-3

mtmt:3253022
Online Access:http://publicatio.bibl.u-szeged.hu/11881
Description
Summary:We carried out whole-exome ultra-high throughput sequencing in brain samples of suicide victims who had suffered from major depressive disorder and control subjects who had died from other causes. This study aimed to reveal the selective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide victims. We also analysed the potential effect of STR and CNV variations, as well as the infection of the brain with neurovirulent viruses in this behavioural disorder. As a result, we have identified several candidate genes, among others three calcium channel genes that may potentially contribute to completed suicide. We also explored the potential implication of the TGF-β signalling pathway in the pathogenesis of suicidal behaviour. To our best knowledge, this is the first study that uses whole-exome sequencing for the investigation of suicide.
Physical Description:Terjedelem: 11 p-Azonosító: 7106
ISSN:2045-2322