Changes in FKBP5 expression and memory functions during cognitive-behavioral therapy in posttraumatic stress disorder a preliminary study /

Posttraumatic stress disorder (PTSD) is characterized by hyperarousal, flashbacks, avoidance, and memory dysfunctions. Although psychotherapy improves the clinical symptoms, its effect on memory has not been explored. In addition, there is no information about gene expression changes related to hipp...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Szabó Csilla
Kelemen Oguz
Kéri Szabolcs
Dokumentumtípus: Cikk
Megjelent: 2014
Sorozat:NEUROSCIENCE LETTERS 569
doi:10.1016/j.neulet.2014.03.059

mtmt:2598446
Online Access:http://publicatio.bibl.u-szeged.hu/11370
Leíró adatok
Tartalmi kivonat:Posttraumatic stress disorder (PTSD) is characterized by hyperarousal, flashbacks, avoidance, and memory dysfunctions. Although psychotherapy improves the clinical symptoms, its effect on memory has not been explored. In addition, there is no information about gene expression changes related to hippocampal functions. We assessed PTSD patients (n=20) using the Wechsler Memory Scale-Revised (WAIS-R) and a paired associates learning (PAL) test, as well as changes in blood FK506 binding protein (FKBP5) mRNA expression before and after cognitive behavioral therapy (CBT). Results revealed that before CBT PTSD patients were impaired on WAIS-R delayed recall, attention/concentration, and PAL compared with trauma-exposed control subjects (n=20). These memory dysfunctions showed a significant improvement after CBT. Better performance on the PAL test correlated with enhanced blood FKBP5 mRNA expression. These results suggest that elevated FKBP5 expression during CBT is related to improved associative memory linked to the hippocampal formation.
Terjedelem/Fizikai jellemzők:116-120
ISSN:0304-3940