Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats
In the present experiment unilateral intrastriatal injections of aminooxyacetic acid (1, 2.5, 5 mumol) to freely moving animals and pentobarbital-anesthetized rats produced contralateral jerks and dose-dependent mortality, but no barrel rotation. At 10-12 days there were no significant differences i...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1992
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| Sorozat: | EUROPEAN JOURNAL OF PHARMACOLOGY
220 |
| doi: | 10.1016/0014-2999(92)90756-T |
| mtmt: | 1032278 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10550 |
| LEADER | 01625nab a2200217 i 4500 | ||
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| 005 | 20190725140444.0 | ||
| 008 | 170215s1992 hu o 0|| zxx d | ||
| 022 | |a 0014-2999 | ||
| 024 | 7 | |a 10.1016/0014-2999(92)90756-T |2 doi | |
| 024 | 7 | |a 1032278 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Vécsei László | |
| 245 | 1 | 0 | |a Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats |h [elektronikus dokumentum] / |c Vécsei László |
| 260 | |c 1992 | ||
| 300 | |a 259-262 | ||
| 490 | 0 | |a EUROPEAN JOURNAL OF PHARMACOLOGY |v 220 | |
| 520 | 3 | |a In the present experiment unilateral intrastriatal injections of aminooxyacetic acid (1, 2.5, 5 mumol) to freely moving animals and pentobarbital-anesthetized rats produced contralateral jerks and dose-dependent mortality, but no barrel rotation. At 10-12 days there were no significant differences in exploratory activity, passive avoidance behavior, and elevated plus-maze test in aminooxyacetic acid-treated animals as compared with controls. However freely moving animals microinjected with aminooxyacetic acid (but not the pentobarbital-pretreated group) had impaired learning activity in an active avoidance conditioning test, and showed reduced striatal concentrations of substance P and GABA. Intrastriatal injections of aminooxyacetic acid therefore result in both acute and chronic behavioral changes which are attenuated by pentobarbital anesthesia. | |
| 700 | 0 | 1 | |a Beal Flint M. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10550/1/Vecsei_L._Aminooxyacetic_acid_u.pdf |z Dokumentum-elérés |