Electrical stimulation of the Gasserian Ganglion induces structural alterations of calcitonin gene-related peptide-immunoreactive perivascular sensory nerve terminals in the rat cerebral dura mater a possible model of migraine headache /
Calcitonin gene-related peptide (CGRP)- positive sensory nerve fibers in the rat supratentorial cerebral dura mater are equipped with varicosities and club-like nerve terminals, often attached to the walls of blood vessels. Brief electrical stimulation of the Gasserian ganglion results in significan...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | NEUROSCIENCE LETTERS
184 |
| doi: | 10.1016/0304-3940(94)11203-U |
| mtmt: | 1164595 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10548 |
| Tartalmi kivonat: | Calcitonin gene-related peptide (CGRP)- positive sensory nerve fibers in the rat supratentorial cerebral dura mater are equipped with varicosities and club-like nerve terminals, often attached to the walls of blood vessels. Brief electrical stimulation of the Gasserian ganglion results in significant swelling and increased immunohistochemical staining of ipsilateral perivascular club-like terminals, while long-lasting electrical stimulation induces their disintegration or bursting, resulting in irregular, corroded outlines of terminals and en passant beads. Stimulation-induced morphological alterations of perivascular terminals may represent a structural basis of increased CGRP content in jugular blood which follows electrical stimulation of the Gasserian ganglion and accompanies migraine attacks. |
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| Terjedelem/Fizikai jellemzők: | 189-192 |
| ISSN: | 0304-3940 |