Simultaneous changes of spatial memory and spine density after intrahippocampal administration of fibrillar abeta1-42 to the rat brain

Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAbeta) peptide represents one of the most frequently used models, mimicking Abeta deposits in the brain. In our experiment synthetic fAbeta1-42 peptide w...

Full description

Saved in:
Bibliographic Details
Main Authors: Borbély Emőke
Horváth János
Furdan Szabina
Bozsó Zsolt
Penke Botond
Fülöp Lívia
Format: Article
Published: Hindawi Publishing Corporation 2014
Series:BIOMED RESEARCH INTERNATIONAL 2014
doi:10.1155/2014/345305

mtmt:2755872
Online Access:http://publicatio.bibl.u-szeged.hu/10505
Description
Summary:Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAbeta) peptide represents one of the most frequently used models, mimicking Abeta deposits in the brain. In our experiment synthetic fAbeta1-42 peptide was administered to rat hippocampus. The effect of the Abeta peptide on spatial memory and dendritic spine density was studied. The fAbeta1-42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAbeta1-42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Abeta-triggered neurodegeneration processes.
Physical Description:Terjedelem: 9 p.-Azonosító: 345305
ISSN:2314-6133