Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats
Sodium azide (20mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the alpha-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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Springer-Verlag
2001
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| Sorozat: | JOURNAL OF NEURAL TRANSMISSION
108 No. 3 |
| doi: | 10.1007/s007020170072 |
| mtmt: | 1032241 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10283 |
| Tartalmi kivonat: | Sodium azide (20mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the alpha-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for alpha-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals. |
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| Terjedelem/Fizikai jellemzők: | 273-278 |
| ISSN: | 0300-9564 |