Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats
RATIONALE AND OBJECTIVES: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. METHODS: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7-19, participated in water maze testing between po...
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| Dokumentumtípus: | Cikk |
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Springer
2002
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| Sorozat: | PSYCHOPHARMACOLOGY
160 No. 1 |
| doi: | 10.1007/s00213-001-0957-2 |
| mtmt: | 105677 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10279 |
| LEADER | 01959nab a2200301 i 4500 | ||
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| 005 | 20190522171614.0 | ||
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| 022 | |a 0033-3158 | ||
| 024 | 7 | |a 10.1007/s00213-001-0957-2 |2 doi | |
| 024 | 7 | |a 105677 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Németh Hajnalka | |
| 245 | 1 | 0 | |a Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats |h [elektronikus dokumentum] / |c Németh Hajnalka |
| 260 | |a Springer |c 2002 | ||
| 300 | |a 1-8 | ||
| 490 | 0 | |a PSYCHOPHARMACOLOGY |v 160 No. 1 | |
| 520 | 3 | |a RATIONALE AND OBJECTIVES: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. METHODS: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7-19, participated in water maze testing between postnatal days 90 and 102, and were then studied electrophysiologically. RESULTS: Treatment with MK-801 in such a low dose resulted in a very slight impairment of performance in the water maze task, but not in the visual cue response. Besides the slight learning impairment, the electrophysiological study revealed a reduction in the capacity for plasticity in the primary motor cortex of the treated animals, which was pronounced in the controls. CONCLUSION: The study demonstrates that even a slight impairment in learning and memory function may be accompanied by a cortical plasticity deficiency that is detectable electrophysiologically. | |
| 700 | 0 | 1 | |a Varga Hedvig |e aut |
| 700 | 0 | 1 | |a Farkas Tamás |e aut |
| 700 | 0 | 1 | |a Kis Zsolt |e aut |
| 700 | 0 | 1 | |a Vécsei László |e aut |
| 700 | 0 | 1 | |a Horváth Szatmár |e aut |
| 700 | 0 | 1 | |a Boda Krisztina |e aut |
| 700 | 0 | 1 | |a Wolff Joachim R. |e aut |
| 700 | 0 | 1 | |a Toldi József |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/10279/1/Nemeth_H._MK_801_u.pdf |z Dokumentum-elérés |