Long-term effects of neonatal MK-801 treatment on spatial learning and cortical plasticity in adult rats
RATIONALE AND OBJECTIVES: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. METHODS: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7-19, participated in water maze testing between po...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
Springer
2002
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| Sorozat: | PSYCHOPHARMACOLOGY
160 No. 1 |
| doi: | 10.1007/s00213-001-0957-2 |
| mtmt: | 105677 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10279 |
| Tartalmi kivonat: | RATIONALE AND OBJECTIVES: The long-term effects of neonatal treatment with MK-801 on spatial learning and cortical plasticity were investigated in adult rats. METHODS: Rat pups were injected twice daily with MK-801 (0.1 mg/kg) on postnatal days 7-19, participated in water maze testing between postnatal days 90 and 102, and were then studied electrophysiologically. RESULTS: Treatment with MK-801 in such a low dose resulted in a very slight impairment of performance in the water maze task, but not in the visual cue response. Besides the slight learning impairment, the electrophysiological study revealed a reduction in the capacity for plasticity in the primary motor cortex of the treated animals, which was pronounced in the controls. CONCLUSION: The study demonstrates that even a slight impairment in learning and memory function may be accompanied by a cortical plasticity deficiency that is detectable electrophysiologically. |
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| Terjedelem/Fizikai jellemzők: | 1-8 |
| ISSN: | 0033-3158 |