A genome-wide screen for association in Hungarian multiple sclerosis

A genome-wide screen for association in Hungarian multiple sclerosis

Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DN...

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Bibliographic Details
Main Authors: Rajda Cecilia
Bencsik Krisztina
Seres Erika
Jonasdottir Aslaug
Foltynie Thomas
Sawcer Stephen
Benediktsson Kjartan
Fossdal Ragnheidur
Setakis Efrosini
Compston Alastair
Vécsei László
Format: Article
Published: 2003
Series:JOURNAL OF NEUROIMMUNOLOGY 143 No. 1-2
doi:10.1016/j.jneuroim.2003.08.017

mtmt:247816
Online Access:http://publicatio.bibl.u-szeged.hu/10270
Description
Summary:Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DNA pools that consisted of 88 MS patients (cases), and 128 unrelated controls. Based on a stringent selection criterion, we obtained 33 markers suggesting association with the disease. (C) 2003 Elsevier B.V. All rights reserved.
Physical Description:84-87
ISSN:0165-5728

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