Identification of selenocompounds with promising properties to reverse cancer multidrug resistance

In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the A...

Full description

Saved in:
Bibliographic Details
Main Authors: Domínguez-Álvarez Enrique
Gajdács Márió
Spengler Gabriella
Palop Juan Antonio
Marć Małgorzata Anna
Kieć-Kononowicz Katarzyna
Amaral Leonard
Molnár József
Jacob Claus
Handzlik Jadwiga
Sanmartín Carmen
Format: Article
Published: Pergamon Press 2016
Series:BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26 No. 12
doi:10.1016/j.bmcl.2016.04.064

mtmt:3076161
Online Access:http://publicatio.bibl.u-szeged.hu/10173
Description
Summary:In previous studies, 56 novel selenoesters and one cyclic selenoanhydride with chemopreventive, antiproliferative and cytotoxic activity were described. Herein, the selenoanhydride and selected selenoesters were evaluated for their ability to reverse the cancer multidrug resistance (MDR) using the ABCB1 efflux pump inhibition assay in mouse MDR T-lymphoma cells. Results showed that the selenoanhydride (1) and the selenoesters with ketone terminal fragments (9-11) exerted (1.7-3.6)-fold stronger efflux pump inhibitory action than the reference verapamil. In addition, those four derivatives triggered apoptotic events in more than 80% of the examined MDR mouse cells. © 2016 Elsevier Ltd.
Physical Description:2821-2824
ISSN:0960-894X