Kynurenine metabolism in plasma and in red blood cells in Parkinson's disease

Substantial evidence indicates that neuroactive kynurenine metabolites play a role in the normal physiology of the human brain, and are involved in the pathology of neurodegenerative disorders such as Parkinson's disease (PD). A sidearm product of the pathway, kynurenic acid (KYNA), which is sy...

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Bibliographic Details
Main Authors: Hartai Zsuzsanna
Klivényi Péter
Janáky Tamás
Penke Botond
Dux László
Vécsei László
Format: Article
Published: 2005
Series:JOURNAL OF THE NEUROLOGICAL SCIENCES 239 No. 1
doi:10.1016/j.jns.2005.07.006

mtmt:1032193
Online Access:http://publicatio.bibl.u-szeged.hu/10086
Description
Summary:Substantial evidence indicates that neuroactive kynurenine metabolites play a role in the normal physiology of the human brain, and are involved in the pathology of neurodegenerative disorders such as Parkinson's disease (PD). A sidearm product of the pathway, kynurenic acid (KYNA), which is synthesized by the in-eversible transamination of kynurenine (KYN) by kynurenine aminotransferases (KAT I and KAT 11), is an excitatory amino acid receptor antagonist. In the present study we measured the level of KYNA and the activities of the biosynthetic enzyme isoforms KAT I and KAT 11 in the plasma and in the erythrocytes (RBC) of 19 PD patients and 17 a-e-matched controls. The KAT I and KAT 11 activities were significantly lower in the plasma of PD patients, followed by a tendency to a decrease in plasma KYNA. An elevated KYNA level con-elated with a significant increase in KAT 11 activity in the RBC of PD patients. These data Support the contribution of an altered KYNA metabolism in the RBC to the pathogenesis of PD. The increased activity of KAT H in correlation with the elevated KYNA level in the RBC may mediate a consecutive protective response against excitatory neurotoxic effects. (c) 2005 Elsevier B.V. All rights reserved.
Physical Description:31-35
ISSN:0022-510X