Binding and partitioning behavior of ketoprofen with surfactants influence of Poloxamer 188 and 407 in preformulation studies /
This study explores the interactions between ketoprofen, a poorly water-soluble NSAID, and three surfactants—sodium cholate (SC), dodecyltrimethylammonium bromide (DTAB), and Brij C10 (BC10)—as well as the modulatory effects of Poloxamer 188 (P188) and Poloxamer 407 (P407). Binding constants were de...
Elmentve itt :
| Szerzők: | |
|---|---|
| Testületi szerző: | |
| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2025
|
| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
31 |
| Kulcsszavak: | Gyógyszerkémia, Fizikai kémia, Kolloidkémia, Gyógyszertechnológia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/88628 |
| Tartalmi kivonat: | This study explores the interactions between ketoprofen, a poorly water-soluble NSAID, and three surfactants—sodium cholate (SC), dodecyltrimethylammonium bromide (DTAB), and Brij C10 (BC10)—as well as the modulatory effects of Poloxamer 188 (P188) and Poloxamer 407 (P407). Binding constants were determined using Benesi-Hildebrand analysis below the critical micelle concentration (CMC), while micellar partitioning was assessed above the CMC using Kawamura’s approach. Job’s plots revealed 1:1 complexation in most systems, with an exception in DTAB/P407 mixtures (1.67:1). DTAB showed the highest affinity for ketoprofen (Kₓ = 81,386), particularly in combination with P188, likely due to favorable electrostatic and hydrophobic interactions. SC and BC10 showed moderate and low solubilizing capacities, respectively. Poloxamers modulated micelle formation by altering CMCs and binding behaviors: P407 exhibited synergistic effects with SC and DTAB, while P188 showed antagonistic effects with SC and BC10. All Gibbs free energies of partitioning (ΔGₓ < 0) indicated spontaneous solubilization, confirming micellar encapsulation as an effective strategy for enhancing ketoprofen solubility. These findings contribute to the rational design of surfactant-based drug delivery systems. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 82-83 |
| ISBN: | 978-963-688-078-1 |