Squalenoylated nanoparticle prodrugs
Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly s...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2024
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
30 |
| Kulcsszavak: | Biokémia, Nanotechnológia, Gyógyszerkémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/85768 |
| Tartalmi kivonat: | Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential. |
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| Terjedelem/Fizikai jellemzők: | 386-387 |
| ISBN: | 978-963-688-009-5 |