A neurohypophysis and adenohypophysis model for the investigation of deponated chemical environmental loads
Persistent organic pollutants, chemicals with high chemical stability and low degradability, widely used in industry and/or agriculture. A heterogeneous group of these compounds include chlorobenzenes (ClB), which are deposited in the lipophilic phases of living organisms and induce dose-dependent t...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2024
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
30 |
| Kulcsszavak: | Biokémia, Környezetkémia, Toxikológia, Molekuláris biológia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/85755 |
| Tartalmi kivonat: | Persistent organic pollutants, chemicals with high chemical stability and low degradability, widely used in industry and/or agriculture. A heterogeneous group of these compounds include chlorobenzenes (ClB), which are deposited in the lipophilic phases of living organisms and induce dose-dependent toxic effects in the cells of affected tissues. The aim of this study was to monitor the effects of different doses of ClB treatments on changes in energy transfer (Mg2+- ATPase) and protein production of neurohypophysis and adenohypophysis. Male Wistar rats were treated with ClB (1:1 mixture of hexachlorobenzene and 1,2,4-trichlorobenzene) in a dose of 1.0 and 10.0 µg /b.w. kg through a gastric tube. Rats were exposed to ClB for 30, 60, and 90 days. The results showed that ClB exposures significantly increased energy transfer and protein production in cell cultures. |
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| Terjedelem/Fizikai jellemzők: | 341-345 |
| ISBN: | 978-963-688-009-5 |