Discovery of ganglioside biomarkers in brain metastasis of lung adenocarcinoma by travelling-wave ion mobility separation mass spectrometry
High performance travelling-wave ion mobility separation mass spectrometry (TWIMS MS) was thoroughly optimized to allow the discovery of brain metastasis of lung adenocarcinoma (BMLA)-specific structures and the assessment of their roles as tumor markers or possible associated antigens. Ganglioside...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2024
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
30 |
| Kulcsszavak: | Tömegspektrometriás analízis, Rákbetegség - diagnosztika - módszer, Molekuláris biológia, Biokémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/85709 |
| Tartalmi kivonat: | High performance travelling-wave ion mobility separation mass spectrometry (TWIMS MS) was thoroughly optimized to allow the discovery of brain metastasis of lung adenocarcinoma (BMLA)-specific structures and the assessment of their roles as tumor markers or possible associated antigens. Ganglioside (GG) separation by TWIMS according to the charge state, carbohydrate chain length, degree of sialylation and ceramide composition, led to the identification of no less than 151 distinct components. The detected GGs and asialo-GGs were found characterized by a high heterogeneity in their ceramide and glycan compositions, encompassing up five Neu5Ac residues. The tumor was found dominated by GM3 and GT1 forms, with a particular incidence of C26 fatty acids in the ceramide. |
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| Terjedelem/Fizikai jellemzők: | 200-201 |
| ISBN: | 978-963-688-009-5 |