Synthesis of red-emitting fluorophores
Understanding the mechanism of action of biologically active compounds is of great interest in medicine, including cancer research. Chemical labeling of molecules, i.e. making them "visible" under the right conditions, is a widespread and intensively researched field of science. The fluore...
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| Dokumentumtípus: | Könyv része |
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2022
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
28 |
| Kulcsszavak: | Kémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/78499 |
| Tartalmi kivonat: | Understanding the mechanism of action of biologically active compounds is of great interest in medicine, including cancer research. Chemical labeling of molecules, i.e. making them "visible" under the right conditions, is a widespread and intensively researched field of science. The fluorescent labeling of compounds offers several advantages over other methods. It might be considered as an environmentally friendly alternative to radioisotope labeling. It is highly important that fluorophores used in biomedical applications meet certain criteria, including high photostability, good cell permeability and stability under physiological conditions. However, the accessibility of the fluorophores is often limited owing to their high price and complex synthetic strategies. Here we synthesized aza-BODIPY fluorophores, which are red-emitting altervatives to BODIPY derivatives. The syntheses were carried out considering the principles of green chemistry. One-pot and/or microwave-assisted syntheses were performed in order to minimize the number of reaction steps and time and use of solvents. |
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| Terjedelem/Fizikai jellemzők: | 170-173 |
| ISBN: | 978-963-306-904-2 |