High energy ionizing radiation induced degradation of ß-blockers in aqueous solutions

Degradation reactions of two beta-blockers, atenolol and propranolol were studied using high energy ionizing irradiation interpreting the outcome of the ongoing radical reactions on the degradation efficiency, oxidation and mineralization processes and toxicity. Under appropriate conditions both hyd...

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Bibliographic Details
Main Authors: Kovács Krisztina
Simon Ádám
Tóth Tünde
Wojnárovits László
Corporate Author: International Symposium on Analytical and Environmental Problems (27.) (2021) (Szeged)
Format: Book part
Published: University of Szeged Szeged 2021
Series:Proceedings of the International Symposium on Analytical and Environmental Problems 27
Kulcsszavak:Analitikai kémia, Béta-blokkolók
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Online Access:http://acta.bibl.u-szeged.hu/75962
Description
Summary:Degradation reactions of two beta-blockers, atenolol and propranolol were studied using high energy ionizing irradiation interpreting the outcome of the ongoing radical reactions on the degradation efficiency, oxidation and mineralization processes and toxicity. Under appropriate conditions both hydroxyl radical (•OH) and hydrated electron (eaq ) take part in degradation reactions. Propranolol showed higher reactivity under both oxidative end reductive conditions than atenolol. Thus it is not surprising that the oxidation and mineralization reactions take place more rapidly due to its condensed ring having higher electron density on the aromatic ring in propranolol. During removal of propranolol toxic products, hydroxylated naphthalene derivatives form. Using appropriate doses the starting molecules can be degraded and the toxic character of the end-products can be eliminated.
Physical Description:188-192
ISBN:978-963-306-835-9