Transport study of kynurenic acid and its newest derivatives through and in vitro model of the blood-brain barrier using targeted UHPLC-MS\MS
We have developed a targeted UHPLC-ESI–MS/MS method for the quantification of kynurenic acid (KYNA) and its derivatives from biological samples. The samples were gained from in vitro permeability assay. We have found that the transportation of the derivatives through the blood-brain barrier is bette...
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| Dokumentumtípus: | Könyv része |
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2020
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Biofizika, Fizikai kémia |
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| Online Access: | http://acta.bibl.u-szeged.hu/74049 |
| Tartalmi kivonat: | We have developed a targeted UHPLC-ESI–MS/MS method for the quantification of kynurenic acid (KYNA) and its derivatives from biological samples. The samples were gained from in vitro permeability assay. We have found that the transportation of the derivatives through the blood-brain barrier is better than KYNA. |
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| Terjedelem/Fizikai jellemzők: | 404-405 |
| ISBN: | 978-963-306-771-0 |