Synthesis of bile acid amines via microwave irradiation
Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, for...
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| Testületi szerző: | |
| Dokumentumtípus: | Könyv része |
| Megjelent: |
2020
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Kémia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/74034 |
| LEADER | 01724naa a2200253 i 4500 | ||
|---|---|---|---|
| 001 | acta74034 | ||
| 005 | 20220808153935.0 | ||
| 008 | 211118s2020 hu o 1|| eng d | ||
| 020 | |a 978-963-306-771-0 | ||
| 040 | |a SZTE Egyetemi Kiadványok Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Vasiljević Bojana | |
| 245 | 1 | 0 | |a Synthesis of bile acid amines via microwave irradiation |h [elektronikus dokumentum] / |c Vasiljević Bojana |
| 260 | |c 2020 | ||
| 300 | |a 344-348 | ||
| 490 | 0 | |a Proceedings of the International Symposium on Analytical and Environmental Problems |v 26 | |
| 520 | 3 | |a Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved. | |
| 650 | 4 | |a Természettudományok | |
| 650 | 4 | |a Kémiai tudományok | |
| 695 | |a Kémia | ||
| 700 | 0 | 1 | |a Prekodravac Jovana |e aut |
| 700 | 0 | 1 | |a Jovanovic Dragana |e aut |
| 710 | |a International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) | ||
| 856 | 4 | 0 | |u http://acta.bibl.u-szeged.hu/74034/1/proceedings_of_isaep_2020_344-348.pdf |z Dokumentum-elérés |