Synthesis of bile acid amines via microwave irradiation
Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, for...
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| Corporate Author: | |
| Format: | Book part |
| Published: |
2020
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| Series: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Kémia |
| Subjects: | |
| Online Access: | http://acta.bibl.u-szeged.hu/74034 |
| Summary: | Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved. |
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| Physical Description: | 344-348 |
| ISBN: | 978-963-306-771-0 |