Microwave-assisted phospha-Michael addition reactions on 13αestrane core
Novel 16-modified 13 α-estrone derivatives were synthesized via phospha-Michael addition reactions. Transformations of steroidal α,β-unsaturated ketons were carried out under different conditions in a microwave (MW) reactor. The antiproliferative activities of the newly synthesized compounds against...
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| Main Authors: | |
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| Corporate Author: | |
| Format: | Book part |
| Published: |
2020
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| Series: | Proceedings of the International Symposium on Analytical and Environmental Problems
26 |
| Kulcsszavak: | Kémia |
| Subjects: | |
| Online Access: | http://acta.bibl.u-szeged.hu/73989 |
| Summary: | Novel 16-modified 13 α-estrone derivatives were synthesized via phospha-Michael addition reactions. Transformations of steroidal α,β-unsaturated ketons were carried out under different conditions in a microwave (MW) reactor. The antiproliferative activities of the newly synthesized compounds against a range of human adherent cancer cell lines (SCC-131, SCC154, Hela, SiHa, C33A, A2780, MCF-7, MDA-MB-231, T47D) were investigated by means of MTT assays. Certain potent derivatives were identified. |
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| Physical Description: | 177-178 |
| ISBN: | 978-963-306-771-0 |