Microwave-assisted phospha-Michael addition reactions on 13αestrane core

Novel 16-modified 13 α-estrone derivatives were synthesized via phospha-Michael addition reactions. Transformations of steroidal α,β-unsaturated ketons were carried out under different conditions in a microwave (MW) reactor. The antiproliferative activities of the newly synthesized compounds against...

Full description

Saved in:
Bibliographic Details
Main Authors: Jójárt Rebeka
Kóczán Lili
Fajka Lilla
Bartha Sándor
Minorics Renáta
Zupkó István
Mernyák Erzsébet
Corporate Author: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Format: Book part
Published: 2020
Series:Proceedings of the International Symposium on Analytical and Environmental Problems 26
Kulcsszavak:Kémia
Subjects:
Online Access:http://acta.bibl.u-szeged.hu/73989
Description
Summary:Novel 16-modified 13 α-estrone derivatives were synthesized via phospha-Michael addition reactions. Transformations of steroidal α,β-unsaturated ketons were carried out under different conditions in a microwave (MW) reactor. The antiproliferative activities of the newly synthesized compounds against a range of human adherent cancer cell lines (SCC-131, SCC154, Hela, SiHa, C33A, A2780, MCF-7, MDA-MB-231, T47D) were investigated by means of MTT assays. Certain potent derivatives were identified.
Physical Description:177-178
ISBN:978-963-306-771-0