Lipid biomarker-based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary)

Lipid biomarker-based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary)

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The perpetual burden of tuberculosis (TB) keeps drawing the focus of research on this disease. Among other risk factors (e.g., poor living conditions, malnutrition, smoking, HIV infection, etc.), being in close contact with a TB infected person requires special attention. For a better understanding...

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Elmentve itt :
Bibliográfiai részletek
Szerzők: Váradi Orsolya A.
Szikossy Ildikó
Spekker Olga
Rakk Dávid
Terhes Gabriella
Urbán Edit
Berthon William
Pap Ildikó
Maixner Frank
Zink Albert
Vágvölgyi Csaba
Donoghue Helen D.
Minnikin David E.
Pálfi György
Szekeres András
Dokumentumtípus: Cikk
Megjelent: 2020
Sorozat:Acta biologica Szegediensis 64 No. 2
Kulcsszavak:Múmia, Embertan, Paleopatológia, Tuberkulózis
Tárgyszavak:
Orvos- és egészségtudomány
Egészségtudományok
Egyéb orvostudományok
doi:10.14232/abs.2020.2.99-109

Online Access:http://acta.bibl.u-szeged.hu/73060
Leíró adatok
Tartalmi kivonat:The perpetual burden of tuberculosis (TB) keeps drawing the focus of research on this disease. Among other risk factors (e.g., poor living conditions, malnutrition, smoking, HIV infection, etc.), being in close contact with a TB infected person requires special attention. For a better understanding of the disease, paleopathological investigations concerning TB have been carried out with various techniques for a long a time; nevertheless, analysis of incidence among family members is hardly possible in past populations. An exceptional group of naturally mummifi ed individuals, the collection of the Vác mummies (Hungary, 18th century CE), is known about the large TB incidence rate, which has been revealed by aDNA analysis. Besides the high rate of TB infection, another interesting aspect of the collection is that in some cases, the family connections could be reconstructed. In this paper, we present the mycocerosic acid profi les gained by HPLC-HESI-MS measurements of two Vác mummies, who were mother and daughter according to the personal records. Earlier metagenomic analysis already revealed mixed M. tuberculosis infection with the same bacterial strains in both individuals; moreover, the same bacterial strains were recorded in both cases.
Terjedelem/Fizikai jellemzők:99-109
ISSN:1588-4082

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