New way to green biological assays fluorescent steroids replace radioisotopes

Novel BODIPY–estrone and BODIPY–estradiol conjugates have been synthesized via Cu(I)- catalyzed azide-alkyne click (CuAAC) and/or Sonogashira reactions by selecting position C3-O for labeling. The steroidal azides and/or bromides were reacted with BODIPY-based fluorescent dye bearing alkyne function...

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Bibliographic Details
Main Authors: Szabó Vivien
Orosz Boglárka Anna
Rigó Réka
Özvegy-Laczka Csilla
Mernyák Erzsébet
Corporate Author: International Symposium on Analytical and Environmental Problems (25.) (2019) (Szeged)
Format: Book part
Published: 2019
Series:Proceedings of the International Symposium on Analytical and Environmental Problems
Kulcsszavak:Szerves kémia
Online Access:http://acta.bibl.u-szeged.hu/64901
Description
Summary:Novel BODIPY–estrone and BODIPY–estradiol conjugates have been synthesized via Cu(I)- catalyzed azide-alkyne click (CuAAC) and/or Sonogashira reactions by selecting position C3-O for labeling. The steroidal azides and/or bromides were reacted with BODIPY-based fluorescent dye bearing alkyne function. The new fluorescent estrone conjugates might replace radiolabeled compounds in certain biochemical assays.
Physical Description:437-438
ISBN:978-963-306-702-4