Synthesis of new fluorine-containing β-amino acid enantiomers through lipase catalyzed hydrolysis
An efficient and novel enzymatic method was developed for the synthesis of β-aryl-fluorinecontaining β-amino acid enantiomers through lipase PS IM (Burkholderia cepasia) catalyzed hydrolysis in i-Pr2O at 45 °C in the presence of Et3N. In order to follow the enzymatic reactions, an adequate analytica...
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| Dokumentumtípus: | Könyv része |
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2019
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
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| Kulcsszavak: | Gyógyszerkémia |
| Online Access: | http://acta.bibl.u-szeged.hu/64888 |
| Tartalmi kivonat: | An efficient and novel enzymatic method was developed for the synthesis of β-aryl-fluorinecontaining β-amino acid enantiomers through lipase PS IM (Burkholderia cepasia) catalyzed hydrolysis in i-Pr2O at 45 °C in the presence of Et3N. In order to follow the enzymatic reactions, an adequate analytical method was devised for the enantioseparation of racemic βamino esters and β-amino acids. |
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| Terjedelem/Fizikai jellemzők: | 392-393 |
| ISBN: | 978-963-306-702-4 |