Environmentally bening catalysis chitosan, a natural ligand for highly enantioselective RU catalyzed transfer hydrogenation of ketones /
We have studied the use of an in situ prepared Ru-chitosan complex in the transfer hydrogenation of prochiral ketones. Reaction of acetophenone and its substituted derivatives resulted in good enantioselectivities in aqueous solvent mixture. To our delight in the reduction of several cyclic ketones...
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| Main Authors: | |
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| Corporate Author: | |
| Format: | Book part |
| Published: |
2017
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| Series: | Proceedings of the International Symposium on Analytical and Environmental Problems
23 |
| Kulcsszavak: | Katalízis - környezetkémia, Fotokatalízis, Szerves kémia |
| Online Access: | http://acta.bibl.u-szeged.hu/56247 |
| Summary: | We have studied the use of an in situ prepared Ru-chitosan complex in the transfer hydrogenation of prochiral ketones. Reaction of acetophenone and its substituted derivatives resulted in good enantioselectivities in aqueous solvent mixture. To our delight in the reduction of several cyclic ketones over 90% enantiomeric excesses were obtained, reaching up to 97% in the transfer hydrogenation of heterocyclic 4-chromanone or 4-thiochromanone derivatives. The pre-prepared Ru-chitosan complex provided identical results even after several months’ storage without special precautions. The complex prepared from a natural, inexpensive, readily available chiral ligand is a convenient alternative of the synthetic ligands, and may be applied in environmentally friendly and sustainable processes for preparing optically pure chiral alcohols. |
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| Physical Description: | 450-452 |
| ISBN: | 978-963-306-563-1 |