Enantioseparation of cyclic β-amino acids on ion-exchangerbased chiral stationary phases
In the present work a direct HPLC method is described for the separation of the stereoisomers of the ampholytic non-methylated, N-methyl-, N-dimethyl- and N-amidino protected cyclic βamino acids through the application of novel Cinchona alkaloid and sulfonic acid-based zwitterionic chiral stationary...
Elmentve itt :
| Szerzők: | |
|---|---|
| Testületi szerző: | |
| Dokumentumtípus: | Könyv része |
| Megjelent: |
2017
|
| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
23 |
| Kulcsszavak: | Analitikai kémia |
| Online Access: | http://acta.bibl.u-szeged.hu/56157 |
| Tartalmi kivonat: | In the present work a direct HPLC method is described for the separation of the stereoisomers of the ampholytic non-methylated, N-methyl-, N-dimethyl- and N-amidino protected cyclic βamino acids through the application of novel Cinchona alkaloid and sulfonic acid-based zwitterionic chiral stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. The enantioseparations were carried out in polar-ionic mobile phase mode in the temperature range 5–40 °C. The effects of the composition of the bulk solvent, the acid and base additive, the temperature, the structures of the ampholytic analytes on the separations were investigated. |
|---|---|
| Terjedelem/Fizikai jellemzők: | 67-69 |
| ISBN: | 978-963-306-563-1 |