Effect of histaminase treatment on histamine and anaphylactic shock in guinea pigs
In guinea pigs, the intravenous injection of histaminase 15 minutes before the intraabdominal injection of 4 mgm. of histamine prevented in most instances the symptoms of histamineshock. Of 10 control animals, all showed marked symptoms within 5 to 7 minutes and 7 animals died shortly after. Of the...
Elmentve itt :
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
1941
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| Sorozat: | Közlemények a szegedi kir. magy. Ferencz József-Tudományegyetem belgyógyászati klinikájáról
Közlemények a szegedi kir. magy. Ferencz József-Tudományegyetem belgyógyászati klinikájáról 1940-1941 |
| Kulcsszavak: | Állatkísérletek, Tengeri malac, Allergia - hisztamin, Anafilaxia, Immunológia |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/54212 |
| Tartalmi kivonat: | In guinea pigs, the intravenous injection of histaminase 15 minutes before the intraabdominal injection of 4 mgm. of histamine prevented in most instances the symptoms of histamineshock. Of 10 control animals, all showed marked symptoms within 5 to 7 minutes and 7 animals died shortly after. Of the 20 animals pretreated with histaminase, 6 showed slight symptoms after 15 minutes, which disappeared in a few minutes in all but 2 animais that died 55 minutes after the injection of the histamine. 2. Histaminase given intravenously 15 minutes before the administration of egg-white intruabdominally to previously sensitized guinea pigs prevented an anaphylactic shock completely in 15 out of 20 animals. The other 5 guinea, pigs showed only very slight symptoms beginning 20 minutes after the injection of egg-white and lasting for a few minutes. Of the 10 control animals all showed severe anaphylactic shock developing within 5 to 10 minutes and 4 animals died 10 to 14 minutes after the injection of the egg-white. |
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| Terjedelem/Fizikai jellemzők: | 1-6 |