Kynurenines and headache

In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission. Glutamate is a k...

Full description

Saved in:
Bibliographic Details
Main Authors: Párdutz Árpád
Fejes-Szabó Annamária
Bohár Zsuzsanna
Tar Lilla
Toldi József
Vécsei László
Format: Article
Published: Springer-Verlag 2012
Series:JOURNAL OF NEURAL TRANSMISSION 119 No. 2
doi:10.1007/s00702-011-0665-y

mtmt:1865153
Online Access:http://publicatio.bibl.u-szeged.hu/9837
Description
Summary:In parallel to serotonin synthesis, the major route of tryptophan catabolism is the kynurenine pathway, which produces neuroactive metabolites. Among these substances, kynurenic acid has potential neuroprotective action blocking glutamate release and glutamatergic neurotransmission. Glutamate is a key player in migraine pathogenesis; it is crucial in the communication of first and second-order neurons, and it has an important role in the genesis of cortical spreading depression, which is the electrophysiological correlate for migraine aura and may be involved in the activation of the trigeminal system. Thus, kynurenines may affect the pathogenesis directly, by acting on glutamate receptors and exerting other neuromodulatory effects, and indirectly via an altered serotonin metabolism. This work summarizes our current results regarding the role of the kynurenine system in trigeminal activation and other events occurring during migraine headache.
Physical Description:285-296
ISSN:0300-9564