Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock
Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion. We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage. Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n = 9) and shock groups (n = 27). Hem...
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| Dokumentumtípus: | Cikk |
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Hindawi Publishing Corporation
2015
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| Sorozat: | BIOMED RESEARCH INTERNATIONAL
2015 |
| doi: | 10.1155/2015/847152 |
| mtmt: | 2965886 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9459 |
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| 024 | 7 | |a 2965886 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Palágyi Péter | |
| 245 | 1 | 0 | |a Monitoring Microcirculatory Blood Flow with a New Sublingual Tonometer in a Porcine Model of Hemorrhagic Shock |h [elektronikus dokumentum] / |c Palágyi Péter |
| 260 | |a Hindawi Publishing Corporation |c 2015 | ||
| 300 | |a Terjedelem: 10 p.-Azonosító: 847152 | ||
| 490 | 0 | |a BIOMED RESEARCH INTERNATIONAL |v 2015 | |
| 520 | 3 | |a Tissue capnometry may be suitable for the indirect evaluation of regional hypoperfusion. We tested the performance of a new sublingual capillary tonometer in experimental hemorrhage. Thirty-six anesthetized, ventilated mini pigs were divided into sham-operated (n = 9) and shock groups (n = 27). Hemorrhagic shock was induced by reducing mean arterial pressure (MAP) to 40 mmHg for 60 min, after which fluid resuscitation started aiming to increase MAP to 75% of the baseline value (60-180 min). Sublingual carbon-dioxide partial pressure was measured by tonometry, using a specially coiled silicone rubber tube. Mucosal red blood cell velocity (RBCV) and capillary perfusion rate (CPR) were assessed by orthogonal polarization spectral (OPS) imaging. In the 60 min shock phase a significant drop in cardiac index was accompanied by reduction in sublingual RBCV and CPR and significant increase in the sublingual mucosal-to-arterial PCO2 gap (PSLCO2 gap), which significantly improved during the 120 min resuscitation phase. There was significant correlation between PSLCO2 gap and sublingual RBCV (r = -0.65, p < 0.0001), CPR (r = -0.64, p < 0.0001), central venous oxygen saturation (r = -0.50, p < 0.0001), and central venous-to-arterial PCO2 difference (r = 0.62, p < 0.0001). This new sublingual tonometer may be an appropriate tool for the indirect evaluation of circulatory changes in shock. | |
| 700 | 0 | 1 | |a Kaszaki József |e aut |
| 700 | 0 | 1 | |a Rostás Andrea |e aut |
| 700 | 0 | 1 | |a Érces Dániel |e aut |
| 700 | 0 | 1 | |a Németh Márton Ferenc |e aut |
| 700 | 0 | 1 | |a Boros Mihály |e aut |
| 700 | 0 | 1 | |a Molnár Zsolt |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/9459/1/Palagyi_Kaszaki_2015_Monitoring_microcirculatory_blood_flow_with_a_new_sublingual_tonometer_probe_u.pdf |z Dokumentum-elérés |