Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols The First Potent 13alpha-d-Secoestrone Derivative. /

The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...

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Bibliographic Details
Main Authors: Szabó Johanna
Jerkovics Nóra
Schneider Gyula
Wölfling János
Bózsity Noémi
Minorics Renáta
Zupkó István
Mernyák Erzsébet
Format: Article
Published: 2016
Series:MOLECULES 21 No. 5
doi:10.3390/molecules21050611

mtmt:3067612
Online Access:http://publicatio.bibl.u-szeged.hu/8291

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