Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols The First Potent 13alpha-d-Secoestrone Derivative. /
The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...
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| Format: | Article |
| Published: |
2016
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| Series: | MOLECULES
21 No. 5 |
| doi: | 10.3390/molecules21050611 |
| mtmt: | 3067612 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8291 |