Synthesis and in Vitro Antiproliferative Evaluation of C-13 Epimers of Triazolyl-d-Secoestrone Alcohols The First Potent 13alpha-d-Secoestrone Derivative. /
The syntheses of C-13 epimeric 3-[(1-benzyl-1,2,3-triazol-4-yl)methoxy]-d-secoestrones are reported. Triazoles were prepared from 3-(prop-2-inyloxy)-d-secoalcohols and p-substituted benzyl azides via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The antiproliferative activities of the products...
Elmentve itt :
Szerzők: |
Szabó Johanna Jerkovics Nóra Schneider Gyula Wölfling János Bózsity Noémi Minorics Renáta Zupkó István Mernyák Erzsébet |
---|---|
Dokumentumtípus: | Cikk |
Megjelent: |
2016
|
Sorozat: | MOLECULES
21 No. 5 |
doi: | 10.3390/molecules21050611 |
mtmt: | 3067612 |
Online Access: | http://publicatio.bibl.u-szeged.hu/8291 |
Hasonló tételek
-
Syntheses and Antiproliferative Effects of D-homo- and D-secoestrones
Szerző: Mernyák Erzsébet, et al.
Megjelent: (2014) -
Synthesis and in vitro investigation of potential antiproliferative monosaccharide-D-secoestrone bioconjugates
Szerző: Bodnár Brigitta, et al.
Megjelent: (2017) -
Mechanism of antiproliferative action of a new D-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility
Szerző: Bózsity Noémi, et al.
Megjelent: (2017) -
Comparative investigation of the in vitro inhibitory potencies of 13-epimeric estrones and D-secoestrones towards 17β-hydroxysteroid dehydrogenase type 1
Szerző: Herman Bianka Edina, et al.
Megjelent: (2016) -
Synthesis of novel 17-(5’-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro
Szerző: Schneider Gyula, et al.
Megjelent: (2015)