Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates
Cation-π interactions to cognate ligands in enzymes have key roles in ligand binding and enzymatic catalysis. We have deciphered the key functional role of both charged and aromatic residues within the choline binding subsite of CTP:phosphocholine cytidylyltransferase and choline kinase from Plasmod...
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| Dokumentumtípus: | Cikk |
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2014-12-01
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| Sorozat: | Angewandte Chemie (International ed. in English)
53 No. 49 |
| doi: | 10.1002/anie.201408246 |
| mtmt: | 2737826 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/7707 |
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| 100 | 1 | |a Nagy Gergell N. | |
| 245 | 1 | 0 | |a Composite aromatic boxes for enzymatic transformations of quaternary ammonium substrates |h [elektronikus dokumentum] / |c Nagy Gergell N. |
| 260 | |c 2014-12-01 | ||
| 300 | |a 13471-13476 | ||
| 490 | 0 | |a Angewandte Chemie (International ed. in English) |v 53 No. 49 | |
| 520 | 3 | |a Cation-π interactions to cognate ligands in enzymes have key roles in ligand binding and enzymatic catalysis. We have deciphered the key functional role of both charged and aromatic residues within the choline binding subsite of CTP:phosphocholine cytidylyltransferase and choline kinase from Plasmodium falciparum. Comparison of quaternary ammonium binding site structures revealed a general composite aromatic box pattern of enzyme recognition sites, well distinguished from the aromatic box recognition site of receptors. | |
| 700 | 0 | 1 | |a Marton Lívia |e aut |
| 700 | 0 | 1 | |a Contet Alicia |e aut |
| 700 | 0 | 1 | |a Ozohanics Olivér |e aut |
| 700 | 0 | 1 | |a Ardelean Laura-Mihaela |e aut |
| 700 | 0 | 2 | |a Rokobné Révész Ágnes |e aut |
| 700 | 0 | 2 | |a Vékey Károly |e aut |
| 700 | 0 | 2 | |a Irimie Florin Dan |e aut |
| 700 | 0 | 2 | |a Vial Henri |e aut |
| 700 | 0 | 2 | |a Cerdan Rachel |e aut |
| 700 | 0 | 2 | |a Vértessy Beáta G. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/7707/1/Nagy%202014.pdf |z Dokumentum-elérés |