High-performance liquid chromatographic separation of unusual β3-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases
Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β3-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chira...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | AMINO ACIDS
47 No. 11 |
| doi: | 10.1007/s00726-015-2006-1 |
| mtmt: | 2968580 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/6002 |
| LEADER | 02243nab a2200301 i 4500 | ||
|---|---|---|---|
| 001 | publ6002 | ||
| 005 | 20180810104700.0 | ||
| 008 | 160118s2015 hu o 0|| zxx d | ||
| 022 | |a 0939-4451 | ||
| 024 | 7 | |a 10.1007/s00726-015-2006-1 |2 doi | |
| 024 | 7 | |a 2968580 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Ilisz István | |
| 245 | 1 | 0 | |a High-performance liquid chromatographic separation of unusual β3-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases |h [elektronikus dokumentum] / |c Ilisz István |
| 260 | |c 2015 | ||
| 300 | |a 2279-2291 | ||
| 490 | 0 | |a AMINO ACIDS |v 47 No. 11 | |
| 520 | 3 | |a Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary β3-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, while in the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary β3-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)™ and ZWIX(-)™ column was observed. On the basis of this intermolecular recognition model between the selectors and the given enantiomers an indirect assignment of the resolved enantiomer via chromatography is proposed. © 2015 Springer-Verlag Wien. | |
| 700 | 0 | 1 | |a Grecsó Nóra |e aut |
| 700 | 0 | 1 | |a Papoušek Roman |e aut |
| 700 | 0 | 1 | |a Pataj Zoltán |e aut |
| 700 | 0 | 1 | |a Barták Petr |e aut |
| 700 | 0 | 1 | |a Lázár László |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Lindner Wolfgang |e aut |
| 700 | 0 | 1 | |a Péter Antal |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/6002/1/ilisz_amino_acids_u.pdf |z Dokumentum-elérés |